Public transport in the city is expensive, but efficient, consisting of an integrated network of fast, modern underground U-Bahn lines, S-Bahn city trains, trams and buses that operate from 4am to 2am. Several night bus routes also operate from 1am. Fares are standard and are based on a zone system; most tickets are valid for an hour and can be used for any amount of transfers between all modes of public transport within that time. A variety of tickets can be bought from machines at most stops including hourly and daily passes, and tickets must be bought prior to boarding; single ticket fares are more expensive during rush hours.

The Frankfurt Card (available from the tourist office) is good value allowing for unlimited travel within greater Frankfurt, plus airport shuttle transport and half price admission to museums. For those attending a conference in Frankfurt, the tourist office has a one-day Congress Ticket valid for unlimited travel in the city and to the airport. Taxis are safe and plentiful, but expensive. Driving a car in the city involves rush hour congestion, expensive parking lots and confusing road systems so it's best to park and use public transport while in the city.